Publications

Complete Bibliography:

Pubmed

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(Lab Member in Bold)

Original Articles:

1.   Sundler Bjorkman L, Pirouzifard M, Grover SP, Egesten A, Sundquist J, Sundquist K, Zoller B. Increased risk of venous thromboembolism in young and middle-aged individuals with hereditary angioedema: a family study. Blood. 2024; 144(4):435–444 (PMID: 38767511)

2. Wan J, Dhrolia S, Kasthuri RR, Prokopenko Y, Ilich A, Saha P, Roest M, Wolberg AS, Key NS, Pawlinski R, Bendapudi PK, Mackman N, Grover SP*. Plasma kallikrein supports FXII-independent thrombin generation in mouse whole blood. Blood Advances. 2024; 8(12):3045-3057 (PMID: 38593231) *Corresponding Author

3.  Grover SP, Snir O, Hindberg K, Englebert TM, Brækkan SK, Morelli VM, Jensen SB, Wolberg AS, Mollnes TE, Ueland T, Mackman N, Hansen JB. High plasma levels of C1-inhibitor are associated with lower risk of future venous thromboembolism. J Thromb Haemost. 2023: In Press (PMID: 37003465)

4. Kawano T, Hisada Y, Grover SP, Schug WJ, Paul DS, Bergmeier W, Mackman N. Decreased Platelet Reactivity and Function in a Mouse Model of Human Pancreatic Cancer. Thromb Haemost. 2023; 123(5):501-509 (PMID: 36716775)

5. Grover SP*, Kawano T, Wan J, Tanratana P, Polai Z, Shim YJ, Snir O, Brækkan S, Dhrolia S, Kasthuri RR, Bendapudi PK, McCrae KR, Wolberg AS, Hansen JB, Farkas H, Mackman N. C1 inhibitor deficiency enhances contact pathway mediated activation of coagulation and venous thrombosis. Blood. 2023; 141(19):2390-2401 (PMID: 36701760) *Corresponding Author

6. Wan J, Tanratana P, Roest M, Gruber A, Pawlinski R, Wolberg AS, Mackman N, Grover SP*. A novel mouse whole blood thrombin generation assay sensitive to FXI- and FIX-mediated amplification of coagulation. Blood Advances. 2022; 7(9):1915-1925 (PMID: 36583671) *Corresponding Author

7. Grover SP, Bharathi V, Posma JJ, Griffin JH, Palumbo J, Mackman N, Antoniak S. Thrombin mediated activation of PAR1 enhances doxorubicin induced cardiac injury in mice. Blood Advances. 2022; 7(10):1945-1953 (PMID: 36477178)

8. Grover SP*, Sundler Bjorkman L, Egesten A, Moll S, Mackman N. Hereditary angioedema is associated with an increased risk of venous thromboembolism. J Thromb Haemost. 2022; 20(11):2703-2706 (PMID: 36053174) *Corresponding Author

9. Lee RH, Kawano T, Grover SP, Bharathi V, Martinez D, Cowley DO, Mackman N, Bergmeier W and Antoniak S. Genetic deletion of platelet PAR4 results in reduced thrombosis and impaired hemostatic plug stability. J Thromb Haemost. 2022; 20: 422-433 (PMID: 34689407)

10. Campbell RA, Hisada Y, Denorme F, Grover SP, Bouck EG, Middleton EA, Wolberg AS, Rondina MT and Mackman N. Comparison of the coagulopathies associated with COVID-19 and sepsis. Res Pract Thromb Haemost. 2021;5:e12525. (PMID: 34027292)

11. Tawil N, Bassawon R, Meehan B, Nehme A, Montermini L, Gayden T, De Jay N, Spinelli C, Chennakrishnaiah S, Choi D, Adnani L, Zeinieh M, Jabado N, Kleinman CL, Witcher M, Riazalhosseini Y, Key NS, Schiff D, Grover SP, Mackman N, Couturier CP, Petrecca K, Suvà ML, Patel A, Tirosh I, Najafabadi H and Rak J. Glioblastoma cell populations with distinct oncogenic programs release podoplanin as procoagulant extracellular vesicles. Blood Adv. 2021;5:1682-1694. (PMID: 33720339)

12.    Hisada Y, Garratt KB, Maqsood A, Grover SP, Kawano T, Cooley BC, Erlich J, Moik F, Flick MJ, Pabinger I, Mackman N and Ay C. Plasminogen activator inhibitor 1 and venous thrombosis in pancreatic cancer. Blood Adv. 2021;5:487-495. (PMID: 33496742)

13.    Prasad JM, Negrón O, Du X, Mullins ES, Palumbo JS, Gilbertie JM, Höök M, Grover SP, Pawlinski R, Mackman N, Degen JL and Flick MJ. Host fibrinogen drives antimicrobial function in. Proc Natl Acad Sci U S A. 2021;118. (PMID: 33443167)

14.    Rosell A, Havervall S, von Meijenfeldt F, Hisada Y, Aguilera K, Grover SP, Lisman T, Mackman N and Thålin C. Patients With COVID-19 Have Elevated Levels of Circulating Extracellular Vesicle Tissue Factor Activity That Is Associated With Severity and Mortality. Arterioscler Thromb Vasc Biol. 2020; 41:878-882. (PMID:33267656)

15.    Grover SP, Olson TM, Cooley BC and Mackman N. Model-dependent contributions of FXII and FXI to venous thrombosis in mice. J Thromb Haemost. 2020;18:2899-2909. (PMID: 33094904)

16.    Grover SP, Bendapudi PK, Yang M, Merrill-Skoloff G, Govindarajan V, Mitrophanov AY and Flaumenhaft R. Injury measurements improve interpretation of thrombus formation data in the cremaster arteriole laser-induced injury model of thrombosis. J Thromb Haemost. 2020;18:3078-3085. (PMID: 32640902)

17.    Mitrophanov AY, Merrill-Skoloff G, Grover SP, Govindarajan V, Kolanjiyil A, Hariprasad DS, Unnikrishnan G, Flaumenhaft R and Reifman J. Injury Length and Arteriole Constriction Shape Clot Growth and Blood-Flow Acceleration in a Mouse Model of Thrombosis. Arterioscler Thromb Vasc Biol. 2020;40:2114-2126. (PMID: 32640902)

18. Grover SP, Schmedes CM, Auriemma AC, Butler E, Parrish ML, Miszta A, Cleuren AC, Visser M, Heitmeier S, Posma JJ, Spronk HM, Antoniak S, Wolberg AS, Pawlinski R, Gailani D and Mackman N. Differential roles of factors IX and XI in murine placenta and hemostasis under conditions of low tissue factor. Blood Adv. 2020;4:207-216. (PMID: 31935292)

19. Schmedes CM, Grover SP, Hisada YM, Goeijenbier M, Hultdin J, Nilsson S, Thunberg T, Ahlm C, Mackman N and Fors Connolly AM. Increased circulating extracellular vesicle tissue factor activity during orthohantavirus infection is associated with intravascular coagulation. J Infect Dis. 2019; 222:1392-1399 (PMID: 31722433)

20. Wu C, Lu W, Zhang Y, Zhang G, Shi X, Hisada Y, Grover SP, Zhang X, Li L, Xiang B, Shi J, Li XA, Daugherty A, Smyth SS, Kirchhofer D, Shiroishi T, Shao F, Mackman N, Wei Y and Li Z. Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis. Immunity. 2019;50:1401-1411.e4. (PMID: 31076358)

21. Hisada Y, Grover SP, Maqsood A, Houston R, Ay C, Noubouossie DF, Cooley BC, Wallén H, Key NS, Thålin C, Farkas Á, Farkas VJ, Tenekedjiev K, Kolev K and Mackman N. Neutrophils and neutrophil extracellular traps enhance venous thrombosis in mice bearing human pancreatic tumors. Haematologica. 2020;105:218-225. (PMID: 31048354)

22. Zhang N, Czepielewski RS, Jarjour NN, Erlich EC, Esaulova E, Saunders BT, Grover SP, Cleuren AC, Broze GJ, Edelson BT, Mackman N, Zinselmeyer BH and Randolph GJ. Expression of factor V by resident macrophages boosts host defense in the peritoneal cavity. J Exp Med. 2019;216:1291-1300. (PMID: 31048328)

23. Grover SP, Saha P, Humphries J, Lyons OT, Patel AS, Serneels J, Modarai B, Mazzone M and Smith A. Inhibition of prolyl hydroxylase domain proteins selectively enhances venous thrombus neovascularisation. Thromb Res. 2018;169:105-112. (PMID: 30031289)

24. Antoniak S, Tatsumi K, Schmedes CM, Grover SP, Pawlinski R and Mackman N. Protease-activated receptor 1 activation enhances doxorubicin-induced cardiotoxicity. J Mol Cell Cardiol. 2018;122:80-87. (PMID: 30098988)

25. Bode MF, Auriemma AC, Grover SP, Hisada Y, Rennie A, Bode WD, Vora R, Subramaniam S, Cooley B, Andrade-Gordon P, Antoniak S and Mackman N. The factor Xa inhibitor rivaroxaban reduces cardiac dysfunction in a mouse model of myocardial infarction. Thromb Res. 2018;167:128-134. (PMID: 29843086)

26. Lyons O, Saha P, Seet C, Kuchta A, Arnold A, Grover SP, Rashbrook V, Sabine A, Vizcay-Barrena G, Patel A, Ludwinski F, Padayachee S, Kume T, Kwak BR, Brice G, Mansour S, Ostergaard P, Mortimer P, Jeffery S, Brown N, Makinen T, Petrova TV, Modarai B and Smith A. Human venous valve disease caused by mutations in in FOXC2 and GJC2. J Exp Med. 2017. 2017;214:2437-2452. (PMID: 28724617)

27. Stopa JD, Baker KM, Grover SP, Flaumenhaft R, Furie B. Kinetic-based trapping by intervening sequence variants of the active sites of protein-disulfide isomerase identifies platelet protein substrates. J Biol Chem, 2017, 292; 9063-9074. (PMID: 28364042)

28. Prysyazhna O, Burgoyne JR, Scotcher J, Grover SP, Kass D, Eaton P. Phosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G Iα Oxidation. J Biol Chem, 2016, 291 (33); 17427-36 (PMID: 27342776)

29. Grover SP, Saha P, Jenkins J, Mukkavilli A, Lyons OT, Patel AS, Sunassee K, Modarai B, Smith A. Quantification of experimental venous thrombus resolution by longitudinal nanogold-enhanced micro-computed tomography. Thromb Res, 2015, 136; 1285-90 (PMID: 26489729)

30. Evans CE, Wadoodi A, Humphries J, Lu X, Grover SP, Saha P, Smith A. Local accumulation of hypoxia-inducible factor 2 alpha during venous thrombus resolution. Thromb Res, 2014, 134; 757-60 (PMID: 25087887)

31. Evans CE, Grover SP, Saha P, Humphries J, Kim JW, Modarai B, Smith A. Suppression of angiogenic response in local vein wall is associated with reduced thrombus resolution. Thromb Res, 2014, 134; 682-5 (PMID: 25042562)

32. Andia ME, Saha P, Jenkins J, Modarai B, Wiethoff AJ, Phinikaridou A, Grover SP, Patel AS, Schaeffter T, Smith A, Botnar RM. Fibrin targeted MRI allows in-vivo quantification of thrombus fibrin content and identifies thrombi amenable for thrombolysis. Arterioscler Thromb Vasc Biol, 2014, 34; 1187-1192 (PMID: 24723557)

33. Evans CE, Grover SP*, Humphries J, Saha P, Patel AP, Patel AS, Lyons O, Modarai B, Smith A. Anti-angiogenic therapy inhibits venous thrombus resolution. Arterioscler Thromb Vasc Biol, 2014, 34; 565-570 (PMID: 2443637) *Joint first author

34. Saha P, Andia ME, Modarai B, Blume U, Humphries J, Patel AS, Phinikaridou A, Evans CE, Mattock K, Grover SP, Ahmad A, Lyons OT, Attia RQ, Renne T, Premaratne S, Wiethoff AJ, Botnar RM, Schaeffter T, Waltham M, Smith A. Magnetic resonance t1-relaxation time of venous thrombus is determined by iron processing and predicts susceptibility to lysis. Circulation, 2013, 128; 729-736 (PMID: 23820077)

35. Patel AS, Smith A, Nucera S, Biziato D, Saha P, Attia RQ, Humphries J, Mattock K, Grover SP, Lyons OT, Guidotti LG, Siow R, Ivetic A, Egginton S, Waltham M, Naldini L, De Palma M, Modarai B. TIE2-expressing monocytes/macrophages regulate revascularization of the ischemic limb. Embo Mol Med, 2013, 5; 858-869 (PMID: 23653322)

 

Reviews

1.  Grover SP*, Mackman N. Anticoagulant SERPINs: Endogenous Regulators of Hemostasis and Thrombosis. Front Cardiovasc Med. 2022; 9: 878199. (PMID: 36053174) *Corresponding Author

2.    Mackman N, Grover SP, Antoniak S. Tissue factor expression, extracellular vesicles, and thrombosis after infection with the respiratory viruses influenza A virus and coronavirus. J Thromb Haemost. 19(11):2652-2658 (PMID: 34418279)

3.    Grover SP*, Hisada YM, Kasthuri RS, Reeves BN and Mackman N. Cancer Therapy-Associated Thrombosis. Arterioscler Thromb Vasc Biol; 41:1291-1305. (PMID: 33567864) *Corresponding Author

4.    Grover SP and Mackman N. Tissue factor in atherosclerosis and atherothrombosis. Atherosclerosis. 2020;307:80-86. (PMID: 32674807)

5.    Grover SP and Mackman N. How useful are ferric chloride models of arterial thrombosis? Platelets. 2020; 31(4):432-438. (PMID: 31608756)

6.    Diaz JA, Saha P, Cooley B, Palmer OR, Grover SP, Mackman N, Wakefield TW, Henke PK, Smith A and Lal BK. Choosing a mouse model of venous thrombosis: a consensus assessment of utility and application. J Thromb Haemost. 2019;17:699-707. (PMID: 30927321)

7.    Posma JJ, Grover SP, Hisada Y, Owens AP, Antoniak S, Spronk HM and Mackman N. Roles of Coagulation Proteases and PARs (Protease-Activated Receptors) in Mouse Models of Inflammatory Diseases. Arterioscler Thromb Vasc Biol. 2019;39:13-24. (PMID: 30580574)

8.    Diaz JA, Saha P, Cooley B, Palmer OR, Grover SP, Mackman N, Wakefield TW, Henke PK, Smith A and Lal BK. Choosing a Mouse Model of Venous Thrombosis. Arterioscler Thromb Vasc Biol. 2019; 39:13-24. (PMID: 30786739)

9.    Grover SP* and Mackman N. Intrinsic Pathway of Coagulation and Thrombosis. Arterioscler Thromb Vasc Biol. 2019;39:331-338. (PMID: 30700128) *Corresponding Author

10.    Grover SP, Bergmeier W and Mackman N. Platelet Signaling Pathways and New Inhibitors. Arterioscler Thromb Vasc Biol. 2018;38:e28-e35. (PMID: 29563117)

11. Grover SP and Mackman N. Tissue Factor: An Essential Mediator of Hemostasis and Trigger of Thrombosis. Arterioscler Thromb Vasc Biol. 2018;38:709-725. (PMID: 29437578)

12. Grover SP, Evans CE, Patel AS, Modarai B, Saha P, Smith A. Assessment of venous thrombosis in animal models, Arterioscler Thromb Vasc Biol, 2016; 36: 245-252 (PMID: 26681755)

13. Albayati MA, Grover SP, Saha P, Lwaleed BA, Modarai B, Smith A. Postsurgical inflammation as a causative mechanism of venous thromboembolism, Semin Thromb Hemost, 2015;41:615-620 (PMID: 26276933)

 

Editorials, commentaries and letters

1.    Grover SP, Sundler Bjorkman L, Egesten A, Moll S, Mackman N. "Hereditary angioedema is associated with an increased risk of venous thromboembolism": reply. J Thromb Haemost. 2023; 21(1): 180-2 (PMID: 36695383

2.    Grover SP and Mackman N. Description of the first mutation in the human tissue factor gene associated with a bleeding tendency. J Thromb Haemost. 2021;19:3-6. (PMID: 33225609)

3.    Hisada Y, Grover SP and Mackman N. Chemotherapy Increases Stroke: Fact or Fiction? Thromb Haemost. 2020;120:534-536. (PMID: 32289856)

4.    Grover SP and Mackman N. Neutrophils, NETs, and immunothrombosis. Blood. 2018;132:1360-1361. (PMID: 30262582)

5.    Grover SP and Roubey RAS. Q10uest for New Therapies to Prevent Antiphospholipid Antibody-Mediated Thrombosis. Arterioscler Thromb Vasc Biol, 2017;37:1801-1802. (PMID: 28954805)