The Grover Lab

ABOUT

Our laboratory's research is aimed at identifying novel mechanisms responsible for pathological activation of coagulation and venous thromboembolism. Venous thromboembolism, including deep vein thrombosis and pulmonary embolism, is a common cardiovascular disease that is a major source of morbidity and mortality worldwide. The mechanisms that drive pathological activation of coagulation and venous thrombosis remain incompletely understood. We contend that a better understanding of these mechanisms will enable identification of at risk populations and novel targets for the development of safe and effective anticoagulants. We are currently exploring the role of C1-inhibitor, an endogenous inhibitor of multiple intrinsic pathway coagulation factors, as an important negative regulator of coagulation and venous thrombosis.

RESEARCH AREAS

• C1-inhibitor and Venous Thrombosis

• The Intrinsic Pathway in Hemostasis and Thrombosis

NEWS

• 10/08/2025: Harish Eswaran and Rohan Kasthuri of the Grover Lab publish on the assoication between caboozantinib and VTE in Blood Advances 

• 09/30/2025: Grover & Bendapudi Labs publish work on SERPING1 and VTE in Blood Advances

• 09/01/2025: Grover & Bendapudi Labs publish work on FXII and VTE in Nature Communications

• 08/31/2025: The Grover Lab moves to the Divison of Hemostasis and Thrombosis at Beth Israel Deaconess Medical Center

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